Research progress on isotope-exchange-based 18F-labeling methods / 中华核医学与分子影像杂志
Chinese Journal of Nuclear Medicine and Molecular Imaging
;
(6): 316-320, 2023.
Article
in Chinese
| WPRIM
| ID: wpr-993598
ABSTRACT
The application of isotope exchange can realize radiolabeling in partially aqueous media, proceed under mild reaction conditions, and exclude complex purification procedure. It is suitable for one-step labeling of sensitive biomolecules with clinical application potential. This review systematically introduces the 18F/ 19F isotope exchange reactions based on carbon and those non-carbon-based reaction centers including silicon, boron, phosphorus, sulfur, gallium and iron. Discussions of the effects on isotope exchange radiochemical yields and molar activities by different reaction types, and labeling conditions and substitute groups on classic labeled substrate are held where possible, as well as recent applications in using these methodologies to develop PET probes.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Nuclear Medicine and Molecular Imaging
Year:
2023
Type:
Article
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