Aplastic Crisis Secondary to Parvovirus B19 Infection
Journal of the Korean Pediatric Society
;
: 1139-1142, 2003.
Article
in Korean
| WPRIM
| ID: wpr-99378
ABSTRACT
Human parvovirus(HPV) B19 infection causes erythema infectiosum in children, sometimes red cell aplastic crisis with hemolytic anemia and chronic bone marrow failure in immunocompromised hosts. HPV B19 is directly cytotoxic for erythroid progenitor cells and inhibits erythropoiesis. Infrequently, HPV B19 inhibits hematopoiesis of three cell lineages and causes transient pancytopenia in patients with hemolytic disorders. We report three patients with hereditary spherocytosis who developed transient aplastic crisis. A HPV B19 infection was confirmed by IgM anti-B19 parvovirus titers and characteristic findings of bone marrow examination as the causative agent associated with severe pancytopenia. Three patients recovered spontaneously after a short period of supportive care with red cell transfusions and intravenous immunoglobulin.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pancytopenia
/
Bone Marrow
/
Bone Marrow Examination
/
Immunoglobulin M
/
Immunoglobulins
/
Erythroid Precursor Cells
/
Immunocompromised Host
/
Erythema Infectiosum
/
Parvovirus
/
Cell Lineage
Limits:
Child
/
Humans
Language:
Korean
Journal:
Journal of the Korean Pediatric Society
Year:
2003
Type:
Article
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