Mechanisms of weight regain after weight loss / 中华内分泌代谢杂志

ABSTRACT

Obesity is a chronic noncommunicable disease with a high tendency to rebound. Although successful weight loss can be achieved with multiple means, weight regain is common. Various compensatory mechanisms underlie such phenomenon, including alterations in adipocytes, energy metabolism, gut hormones, central appetite modulation, and gut microbiome. These changes may interact with each other through gut-brain axis, and influence long-term weight maintenance. The present review focuses on potential mechanisms of weight regain to shed light on further research in this field.