Expression of TGF-alpha, beta1, beta2 in Pterygial Mast cell
Journal of the Korean Ophthalmological Society
;
: 1261-1268, 2002.
Article
in Korean
| WPRIM
| ID: wpr-99454
ABSTRACT
PURPOSE:
To evaluate whether TGF-alpha, beta1, beta2 are expressed in pterygial mast cell and the difference between each growth factor exists.METHODS:
We prepared 10 pieces each of excised normal conjunctiva, primary pterygium, recurrent pterygium from human eyes and then fixed those in 4% paraformaldehyde solution. The tissues were embedded in paraffin and slide samples taken from those. After that, we observed mast cells stained by immunohistochemistry against each of TGF-alpha,beta1 ,beta2 and compared the staining features between them, and we also confirmed metachromatic staining of the mast cell with toluidine blue.RESULTS:
As compared with normal conjunctiva, in primary and recurrent pterygia, those counts of mast cells expressing TGF-alpha, beta1, beta2 were increased respectively with statistical significance and especially, those counts for TGF-beta1 in primary pterygium were 9 times as high as in normal conjunctiva.CONCLUSIONS:
Pterygial mast cells are considered to play an important role in fibrovascular proliferation of pterygium by synthesizing and secretion of TGF-alpha, beta1, beta2 . Especially, TGF-beta1 is thought to play a more important role than TGF-alphaandbeta2 in primary pterygium.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Paraffin
/
Tolonium Chloride
/
Pterygium
/
Immunohistochemistry
/
Transforming Growth Factor alpha
/
Conjunctiva
/
Transforming Growth Factor beta1
/
Mast Cells
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Ophthalmological Society
Year:
2002
Type:
Article
Similar
MEDLINE
...
LILACS
LIS