Association of microsatellite instability with clinicopathological features and prognosis of colon cancer patients / 中华普通外科杂志

ABSTRACT

Objective:To investigate the relationship between microsatellite instability (MSI) , and clinicopathological features ,prognosis in patients with stage Ⅱ and Ⅲ colon cancer.Methods:Patients undergoing surgical resection for stage Ⅱ and Ⅲ colonic tumor in the Affiliated Hospital of Qingdao University from Dec 2016 to Nov 2018 were enrolled. All the 292 patients were with stage Ⅱ and Ⅲ colon cancer and MSI status. Propensity score matching method was used to match the two groups of patients according to 11. χ 2 analysis, Logistic Regression and COX regression was used to analyse the relationship between MSI status, the clinicopathological features and prognosis. Results:The risk of MSI-H in young patients ( OR=0.340, 95% CI 0.126~0.921, P=0.034), right-sided colon cancer ( OR=7.985, 95% CI 3.040-20.973, P<0.001), mucinous adenocarcinoma ( OR=4.285, 95% CI 1.495-12.284, P=0.007), poorer differentiation ( OR=4.848, 95% CI 1.597-14.716, P=0.005), N0 staging ( OR=0.235 , 95% CI 0.077-0.719, P=0.011) increased . The total OS of colon cancer patients in the MSS group (66.7%) and the MSI-H group (86.9%) were statistically different( P=0.003). The MSI status ( HR=0.367, 95% CI 0.151-0.891, P=0.027) is an independent factor affecting the prognosis of patients. Conclusions:In stage Ⅱ and Ⅲ colon cancer, patients with MSI-H have a better prognosis. MSI status is prognosis relevant factor for colon cancer patients.