Clinical Significance of Anti-endothelial Cell Antibody in Renal Transplant Recipients
The Korean Journal of Internal Medicine
;
: 24-29, 2001.
Article
in English
| WPRIM
| ID: wpr-99479
ABSTRACT
In order to evaluate the role of anti-endothelial cell antibody (AECA) in acute rejection in renal transplantation, serum AECA IgG titers were measured in 68 healthy controls, 111 chronic hemodialysis (HD) patients and 58 first renal transplant recipients. The AECA titer in hemodialysis patients was higher than in healthy controls (13.9+/-5.0 vs. 4.8+/-2.3 U/mL, p0.05). After renal transplantation, AECA titer was decreased significantly (vs. 4.7+/-3.6 U/mL, p<0.01). The serum AECA IgG titers increased significantly in recipients with acute rejection (6.9+/-3.1 vs. 13.5+/-9.9 U/mL, p<0.01), but decreased to 5.6+/-3.0 U/mL (p<0.01) after formal rejection therapy. In the recipients with acute rejection (n=27), the pre-renal transplant AECA titer was higher than in that without acute rejection (14.0+/-8.6 vs. 7.7+/-3.8 U/mL, p<0.01). The results of this study lead us to conclude that pre- and post-renal transplant AECA titer might be a useful predictor for acute rejection and useful for monitoring acute rejection in renal transplant recipients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Reference Values
/
Autoantibodies
/
Transplantation Immunology
/
Enzyme-Linked Immunosorbent Assay
/
Comparative Study
/
Biomarkers
/
Probability
/
Sensitivity and Specificity
/
Renal Dialysis
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
The Korean Journal of Internal Medicine
Year:
2001
Type:
Article
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