Research progresses on the role of short-chain fatty acids in the pathogenesis of Parkinson′s disease / 中华神经科杂志

ABSTRACT

In recent years, a number of studies have found that the dysregulation of intestinal microbes and their metabolites plays an important role in the occurrence and development of Parkinson′s disease (PD), and is closely related to the severity of PD clinical symptoms. Short-chain fatty acids are the main metabolites of intestinal microorganisms and may be involved in the pathogenesis of PD by regulating the inflammatory response, neuronal autophagy and apoptosis and the integrity of the blood-brain barrier and intestinal barrier. In this paper, the research progresses on the role of short-chain fatty acids in the pathogenesis of PD are reviewed, in order to provide new ideas for the treatment of PD.