Progress in the function of nucleoporin 50 and its relationship with viral infection / 中华微生物学和免疫学杂志

ABSTRACT

Nucleoporin 50 (Nup50) is a component of nuclear basket in nuclear pore complex. It includes three main domains N domain binding to importin α, F domain binding to importin β and R domain binding to Ran. The N domain has two importin α-binding segments. There are mainly two models for explaining the role of Nup50 in nuclear import tri-stable switch and disassemble-recycle model. Nup50 not only participates in nuclear import, but also regulates genome organization and gene expression. In addition, Nup50 is involved in the process of viral infection and replication. There is some evidence that Nup50 is related to hepatitis B virus and human immunodeficiency virus 1 infections. However, there are few researches on the relationship between Nup50 and viral infection. This article summarized the progress in the function of Nup50 and its relationship with viral infection, aiming to provide new ideas for the following in-depth study.