Application and consideration of metabolomics detection in embryo culture medium in the noninvasive screening of embryos / 中华检验医学杂志

ABSTRACT

In vitro fertilization (IVF) is the most successful and efficient approach to infertility treatment. Choosing the appropriate embryos for transfer significantly decreases the pregnancy failure rate and improves IVF results. Invasive procedure to acquire embryo DNA has a significant limitation. The differences of metabolites, nucleic acids, proteins and other components in embryo medium can help to screen embryos with potential development to improve implantation rate and pregnancy rate, reduce abortion rate and avoid the transfer of aneuploid embryos and the transmission of mutated genes to offspring. The metabolomics screening of high developmental potential embryos with embryo culture medium can assess the developmental potential of embryos comprehensively, objectively and noninvasiveness, which is crucial for improving the pregnancy rate of single embryo transfer.