Progress in mechanism and application of granulocyte-macrophage colony-stimulating factor for prevention and treatment of tumor chemoradiotherapy-induced mucositis / 肿瘤研究与临床

ABSTRACT

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a multifunctional hematopoietic growth factor that can promote the recovery of leukopenia caused by tumor chemoradiotherapy, and can also prevent chemoradiotherapy-induced mucositis by promoting a variety of cells such as endothelial cells, epithelial cells, keratinocytes and fibroblasts. This article reviews the domestic and foreign basic and clinical research progress of GM-CSF in recent years, and discusses the mechanism and clinical application of GM-CSF as a mucosal repair agent in the prevention and treatment of tumor chemoradiotherapy-induced mucositis.