Short period Clinical Observations of Cerebral Palsied Children with Athetosis Treated with Madopar / 中国康复理论与实践

ABSTRACT

@# In this paper,we studied the clinical effects,side effects,doses ,dosing interval,relations between doses and effects of using Madopar in 61 children with athetoid cerebral palsy.Taking ADL Evaluation Scheme for Cerebral Palsied Children as main efficacy value,very marked statistic difference exists when two groups with or without Madopar were assessed on the third evaluation in our study,and it shows the effects of Madopar while its adverse events are mild and transient.The average and maximal initial dose is 9mg/kg/d and 26mg/kg/d respectively,and the average titration interval is one week while the shortest inetrval is a day.It can be titrated to 20mg/kg/d on average and 38mg/kg/d on maximal dose.There was no correlation between doses and effects.Suggestion was made for further investigation.