Accuracy Assessment of Five Equations Used for Estimating the Glomerular Filtration Rate in Korean Adults
Annals of Laboratory Medicine
;
: 371-380, 2017.
Article
in English
| WPRIM
| ID: wpr-99762
ABSTRACT
BACKGROUND:
We aimed to assess the performance of the five creatinine-based equations commonly used for estimates of the glomerular filtration rate (eGFR), namely, the creatinine-based Chronic Kidney Disease Epidemiology Collaboration (CKD-EPIcr), Asian CKD-EPI, revised Lund–Malmö (revised LM), full age spectrum (FAS), and Korean FAS equations, in the Korean population.METHODS:
A total of 1,312 patients, aged 20 yr and above who underwent ⁵¹Cr-EDTA GFR measurements (mGFR), were enrolled. The bias (eGFR–mGFR) and precision (root mean square error [RMSE]) were calculated. The accuracy (P30) of four eGFR equations was compared to that of the CKD-EPIcr equation. P30 was defined as the percentage of patients whose eGFR was within±30% of the mGFR.RESULTS:
The mean bias (mL·min⁻¹·1.73 m⁻²) of the five eGFR equation was as follows CKD-EPIcr, -0.6; Asian CKD-EPI, 2.7; revised LM, -6.5; FAS, -2.5; and Korean FAS, -0.2. The bias of the Asian CKD-EPI, revised LM, and FAS equations showed a significant difference from zero (P<0.001). The RMSE values were as follows CKD-EPIcr, 15.6; Asian CKD-EPI, 15.6; revised LM, 17.9; FAS, 16.3; and Korean FAS, 15.8. There were no significant differences in the P30 except for the Asian CKD-EPI equation CKD-EPIcr, 76.6%; Asian CKD-EPI, 74.7%; revised LM, 75.8%; FAS, 76.0%; and Korean FAS, 75.8%.CONCLUSIONS:
The CKD-EPIcr and Korean FAS equations showed equivalent analytical and clinical performances in the Korean adult population.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Bias
/
Epidemiology
/
Cooperative Behavior
/
Creatinine
/
Asian People
/
Renal Insufficiency, Chronic
/
Glomerular Filtration Rate
Limits:
Adult
/
Humans
Language:
English
Journal:
Annals of Laboratory Medicine
Year:
2017
Type:
Article
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