Advances in research on small molecule regulators targeting HBV cccDNA generation and transcription / 药学学报
Acta Pharmaceutica Sinica
;
(12): 2979-2994, 2023.
Article
in Chinese
| WPRIM
| ID: wpr-999040
ABSTRACT
Hepatitis B virus (HBV) represents a significant global public health challenge. Despite the availability of several approved drugs for hepatitis B treatment, the persistence of covalently closed circular DNA (cccDNA) renders HBV eradication elusive, thereby leading to disease relapse after drug withdrawal. This paper reviews the regulatory mechanisms of cccDNA formation, transcription and replication, and summarizes the research progress of related small molecule regulators from the perspective of medicinal chemistry.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2023
Type:
Article
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