Effects of Ondansetron on the Neuromuscular Block of Vecuronium, Rocuronium or Atracurium in a Rat Phrenic Nerve-Hemidiaphragm Preparation / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 650-655, 2003.
Article
in Korean
| WPRIM
| ID: wpr-9992
ABSTRACT
BACKGROUND:
Ondansetron, a 5-HT3 receptor antagonist, is widely used for the prevention of postoperative nausea and vomiting. However, the interaction of ondansetron with non-depolarizing muscle relaxants have not been reported until now. Therefore we studied the effects of ondansetron on the neuromuscular block of vecuronium, rocuronium or atracurium in vitro.METHODS:
A square wave 0.1 Hz supramaximal stimuli was applied to the phrenic nerve-hemidiaphragm preparation of a rat, and the twitch height response was recorded mechanomyographically. We measured cumulative concentration response curves of vecuronium, rocuronium or atracurium alone and after pretreating with ondansetron (1microgram/ml). We also measured the effects of ondansetron. The EC50's and EC90's of these muscle relaxants alone and after pretreatment with ondansetron were calculated using an inhibitory sigmoid Emax model.RESULTS:
Ondansetron depressed the twitch height in a dose-dependent manner, and its potency was lower than the muscle relaxants. The EC50 and EC90 of ondansetron were 14.7microgram/ml and 33.4microgram/ml, respectively. Pretreated ondansetron (1microgram/ml) significantly reduced the EC50's and EC90's of vecuronium, rocuronium and atracurium (P<0.05).CONCLUSIONS:
Ondansetron itself may have neuromuscular blocking properties, and it significantly enhances the neuromuscular blocks induced by vecuronium, rocuronium or atracurium.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Colon, Sigmoid
/
Atracurium
/
Vecuronium Bromide
/
Ondansetron
/
Neuromuscular Nondepolarizing Agents
/
Neuromuscular Blockade
/
Postoperative Nausea and Vomiting
/
Receptors, Serotonin, 5-HT3
Limits:
Animals
Language:
Korean
Journal:
Korean Journal of Anesthesiology
Year:
2003
Type:
Article
Similar
MEDLINE
...
LILACS
LIS