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The role of H1- and H2-receptors in the effect of compound 48/80 in the asphyxiation and body temperature of mice
Yonsei Medical Journal ; : 97-103, 1996.
Article in English | WPRIM | ID: wpr-99934
ABSTRACT
Contribution of histamine H1- and H2-receptors to the effect of compound 48/80, a potent histamine releaser, upon asphyxiation and body temperature in mice was investigated in the present experiments. Compound 48/80 showed an apparent protective potency against hypoxia and significantly prolonged the latencies for convulsions and death in a dose-dependent manner. Compound 48/80 also decreased the body temperature, which was in relation with the antihypoxic effect. Both the H1-receptor antagonist, dimethindene, and the H2-receptor antagonist, ranitidine, attenuated the hypothermic effect of compound 48/80, indicating the involvement of central histamine through both the H1- and H2-receptors. Ranitidine had no effect on the protective effect of compound 48/80 against hypoxia-induced lethality, whereas dimethindene completely antagonized it. These results suggest that the protective effect of compound 48/80 against hypoxia is mediated through histamine H1-receptors and is not related to its ability to induce hypothermia.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Seizures / Body Temperature / Receptors, Histamine H1 / Receptors, Histamine H2 / P-Methoxy-N-methylphenethylamine / Animals / Hypoxia / Mice, Inbred BALB C Limits: Animals Language: English Journal: Yonsei Medical Journal Year: 1996 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Seizures / Body Temperature / Receptors, Histamine H1 / Receptors, Histamine H2 / P-Methoxy-N-methylphenethylamine / Animals / Hypoxia / Mice, Inbred BALB C Limits: Animals Language: English Journal: Yonsei Medical Journal Year: 1996 Type: Article