Chromatographic Determination of the Absolute Configuration in Sanjoinine A That Increases Nitric Oxide Production
Biomolecules & Therapeutics
;
: 566-572, 2023.
Article
in English
| WPRIM
| ID: wpr-999703
ABSTRACT
A chiral derivatization strategy with phenylglycine methyl ester (PGME) was employed to develop a straightforward method to determine the absolute configurations of N,N-dimethyl amino acids. The PGME derivatives were analyzed using liquid chromatography-mass spectrometry to identify the absolute configurations of various N,N-dimethyl amino acids based on their elution time and order. The established method was applied to assign the absolute configuration of the N,N-dimethyl phenylalanine in sanjoinine A (4), a cyclopeptide alkaloid isolated from Zizyphi Spinosi Semen widely used as herbal medicine for insomnia. Sanjoinine A displayed production of nitric oxide (NO) in LPS-activated RAW 264.7 cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
English
Journal:
Biomolecules & Therapeutics
Year:
2023
Type:
Article
Similar
MEDLINE
...
LILACS
LIS