Your browser doesn't support javascript.
loading
A systematic review on the influence of hla-b polymorphisms on hiv-1 mother-to-child-transmission
Angulo, Juan Manuel Cubillos; Cuesta, Taryn Ariadna Castro; Menezes, Eliane Pereira; Pedroso, Celia; Brites, Carlos.
  • Angulo, Juan Manuel Cubillos; Universidade Federal da Bahia. Complexo Hospitalar Prof. Edgard Santos. Laboratório de Pesquisa em Infectologia. Salvador. BR
  • Cuesta, Taryn Ariadna Castro; Universidade Federal da Bahia. Programa de Pós-Graduação em Medicina e Saúde. Salvador. BR
  • Menezes, Eliane Pereira; Universidade Federal da Bahia. Faculdade de Medicina. Departamento de Medicina. Salvador. BR
  • Pedroso, Celia; Universidade Federal da Bahia. Complexo Hospitalar Prof. Edgard Santos. Laboratório de Pesquisa em Infectologia. Salvador. BR
  • Brites, Carlos; Universidade Federal da Bahia. Complexo Hospitalar Prof. Edgard Santos. Laboratório de Pesquisa em Infectologia. Salvador. BR
Braz. j. infect. dis ; 23(1): 53-59, Jan.-Feb. 2019. tab, graf
Artículo en Inglés | LILACS | ID: biblio-1001501
ABSTRACT
ABSTRACT

Background:

Mother-to-child-transmission (MTCT) is the main route of HIV-1 infection in children. Genetic studies suggest HLA-B alleles play an important role on HIV-1 transmission, progression, and control of HIV-1 infection.

Objective:

To evaluate which polymorphisms of HLA-B are involved in HIV-1 MTCT.

Methods:

Two independent reviewers performed a systematic review on search engines PubMed, Europe PMC, Cochrane, Scientific Electronic Library Online (SciELO), and Literatura Latino-americana e do Caribe em Ciências da Saúde (Lilacs), using the following key terms "HIV infection", "HIV newborn", "HLA polymorphisms", "HLA-B", and "Mother to child transmission". All studies focusing on evaluation of HIV-1 MTCT, HIV infection evolution, and molecular analyses of HLA-B in children were selected.

Results:

Nine studies fulfilled the inclusion criteria. Sixteen HLA-B alleles groups were associated with HIV-1 infection; seven of them (43.8%) were related to slow disease progression or reduced risk of MTCT, while six (37.5%) alleles groups were linked to a faster progression of HIV infection in children and to increased risk of MTCT. The available evidence suggest that HLA-B*57 group allele is associated with slow disease progression, while HLA-B*35 group allele is associated to increased risk of MTCT and rapid disease progression in infected children. The role of HLA-B*18, B*58 and B*44 are still controversial because they were associated to both, protection against MTCT, and to higher HIV replicative capacity, in different studies.

Conclusion:

HLA-B*57 group allele can be protective against MTCT while HLA-B*35 groups alleles are consistently associated with HIV-1 MTCT.
Asunto(s)


Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Polimorfismo Genético / Antígenos HLA-B / Infecciones por VIH / Transmisión Vertical de Enfermedad Infecciosa Tipo de estudio: Estudio de etiología / Factores de riesgo / Revisiones Sistemáticas Evaluadas Límite: Humanos Idioma: Inglés Revista: Braz. j. infect. dis Asunto de la revista: Enfermedades Transmisibles Año: 2019 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Universidade Federal da Bahia/BR

Similares

MEDLINE

...
LILACS

LIS


Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Polimorfismo Genético / Antígenos HLA-B / Infecciones por VIH / Transmisión Vertical de Enfermedad Infecciosa Tipo de estudio: Estudio de etiología / Factores de riesgo / Revisiones Sistemáticas Evaluadas Límite: Humanos Idioma: Inglés Revista: Braz. j. infect. dis Asunto de la revista: Enfermedades Transmisibles Año: 2019 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Universidade Federal da Bahia/BR