Pharmacokinetics of oleracimine in rats by ultra-high-performance liquid chromatography
Braz. J. Pharm. Sci. (Online)
;
54(4): e17242, 2018. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-1001571
ABSTRACT
The novel alkaloid, oleracimine, presented remarkable anti-inflammatory bioactivity, and therefore, its pharmacokinetics was investigated in rat plasma after intravenous and oral administration by using a rapid ultra-high-performance liquid chromatography (UHPLC) method with UV detection at 270 nm. The analysis was performed on a shim-pack ODS column (75 mm×2 mm, 1.6 µm particle size, Shimadzu, Japan) column using isocratic elution with a mobile phase consisting of methanol-water (6238, v/v) within 3 min. The results indicated that oleracimine was rapidly distributed with Tmax for 11.7 min after oral administration, which presented the double-peak phenomenon in the pharmacokinetic profile with a higher oral absolute bioavailability of 55.1% ± 7.83%.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Farmacocinética
/
Cromatografía Liquida
/
Portulaca
Límite:
Animales
Idioma:
Inglés
Revista:
Braz. J. Pharm. Sci. (Online)
Asunto de la revista:
Farmacologia
/
Teraputica
/
Toxicologia
Año:
2018
Tipo del documento:
Artículo
País de afiliación:
China
Institución/País de afiliación:
Liaoning University of Traditional Chinese Medicine/CN
/
National Institute for Radiological Protection/CN
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