Importancia de la orientación diagnóstica en hemofilia A adquirida / Adequate diagnosis of acquired hemophilia A
Rev. méd. Chile
;
147(3): 334-341, mar. 2019. tab, graf
Artículo
en Español
| LILACS
| ID: biblio-1004354
ABSTRACT
Acquired hemophilia A (AHA) is a rare and life-threatening autoimmune hemorrhagic disorder where autoantibodies are developed against factor VIII. An early diagnosis is challenging and mandatory: an immediate hemostatic control is required to reduce morbidity and mortality. Laboratory features of AHA are: presence of autoantibodies against factor VIII, prolonged activated partial thromboplastin time (with normal prothrombin time and thrombin time) and decreased factor VIII levels. In some cases, the results of laboratory tests may be incorrect due to errors in analysis, blood extraction or manipulation of samples; also worth of consideration are limitations in the measurement range and low sensitivity of the tests. This review highlights the importance of adequate screening in patients with suspected AHA to make an adequate diagnosis and reduce overall fatal outcomes.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Hemofilia A
Tipo de estudio:
Estudio diagnóstico
/
Estudio de tamizaje
Límite:
Humanos
Idioma:
Español
Revista:
Rev. méd. Chile
Asunto de la revista:
Medicina
Año:
2019
Tipo del documento:
Artículo
País de afiliación:
Colombia
Institución/País de afiliación:
Fundación Universitaria de Ciencias de la Salud/CO
/
Hospital La Misericordia/CO
/
Hospital Pablo Tobón Uribe/CO
/
NeuroEconomix/CO
/
Organización Sanitas/CO
Similares
MEDLINE
...
LILACS
LIS