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In properly selected patients with differentiated thyroid cancer, antithyroglobulin antibodies decline after thyroidectomy and their sole presence should not be an indication for radioiodine ablation
Zavala, Luis Felipe; Barra, María Inés; Olmos, Roberto; Tuttle, Michael; González, Hernán; Droppelmann, Nicolás; Mosso, Lorena; Domínguez, José M.
  • Zavala, Luis Felipe; Pontificia Universidad Católica de Chile. Faculty of Medicine. Departments of Endocrinology. Santiago. CL
  • Barra, María Inés; Pontificia Universidad Católica de Chile. Faculty of Medicine. Departments of Endocrinology. Santiago. CL
  • Olmos, Roberto; Pontificia Universidad Católica de Chile. Faculty of Medicine. Departments of Endocrinology. Santiago. CL
  • Tuttle, Michael; Memorial Sloan-Kettering Cancer Center. Department of Endocrinology Service. New York. US
  • González, Hernán; Pontificia Universidad Católica de Chile. Faculty of Medicine. Santiago. CL
  • Droppelmann, Nicolás; Pontificia Universidad Católica de Chile. Faculty of Medicine. Santiago. CL
  • Mosso, Lorena; Pontificia Universidad Católica de Chile. Faculty of Medicine. Departments of Endocrinology. Santiago. CL
  • Domínguez, José M; Pontificia Universidad Católica de Chile. Faculty of Medicine. Departments of Endocrinology. Santiago. CL
Arch. endocrinol. metab. (Online) ; 63(3): 293-299, May-June 2019. tab
Artículo en Inglés | LILACS | ID: biblio-1011157
ABSTRACT
ABSTRACT Objective Our objective was to evaluate the trend of antithyroglobulin antibodies (TgAb) during follow-up of patients with differentiated thyroid cancer (DTC) treated without RAI, as well as their role in the risk of recurrence. Subjects and methods This was a prospective, descriptive study. A total of 152 consecutive patients with DTC treated in a single institution undergoing total thyroidectomy without RAI and followed for a median of 2.3 years (0.5-10.3) were divided in two groups TgAb(-) (n = 111) and TgAb(+) (n = 41). Patients were classified according to AJCC 7th and 8th editions, as well as to their risk of recurrence and response to treatment categories. Results Both groups, TgAb(-) and TgAb(+), were similar regarding patient and tumor characteristics. At the end of follow-up, 90 (59.2%), 57 (37.5%), 3 (2%) and 2 (1.3%) patients achieved excellent, indeterminate, biochemically incomplete and structurally incomplete response, respectively. The risk of structural recurrence was similar in both groups (TgAb[-] 0.9% vs. TgAb[+] 2.4%, p = 0.46). In the TgAb(+) group, TgAb became negative in 10 (24.4%), decreased ≥ 50% without negativization in 25 (60.9%), decreased < 50% in 4 (9.8%) and remained stable or increased in 2 (4.9%) cases. The only incomplete structural response had increasing TgAb during follow-up. Conclusions In properly selected patients with DTC, TgAb concentration immediately after total thyroidectomy should not mandate RAI ablation, and their trend during follow-up may impact the risk of recurrence.
Asunto(s)


Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Autoanticuerpos / Neoplasias de la Tiroides / Radioisótopos de Yodo Tipo de estudio: Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Adolescente / Adulto / Anciano / Aged80 / Femenino / Humanos / Masculino Idioma: Inglés Revista: Arch. endocrinol. metab. (Online) Asunto de la revista: Endocrinologia / Metabolismo Año: 2019 Tipo del documento: Artículo País de afiliación: Chile / Estados Unidos Institución/País de afiliación: Memorial Sloan-Kettering Cancer Center/US / Pontificia Universidad Católica de Chile/CL

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Autoanticuerpos / Neoplasias de la Tiroides / Radioisótopos de Yodo Tipo de estudio: Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Adolescente / Adulto / Anciano / Aged80 / Femenino / Humanos / Masculino Idioma: Inglés Revista: Arch. endocrinol. metab. (Online) Asunto de la revista: Endocrinologia / Metabolismo Año: 2019 Tipo del documento: Artículo País de afiliación: Chile / Estados Unidos Institución/País de afiliación: Memorial Sloan-Kettering Cancer Center/US / Pontificia Universidad Católica de Chile/CL