MTHFR gene polymorphisms in hypothyroidism and hyperthyroidism among Jordanian females
Arch. endocrinol. metab. (Online)
;
63(3): 280-287, May-June 2019. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-1011172
ABSTRACT
ABSTRACT Objective Methylenetetrahydrofolate reductase (MTHFR) is involved in DNA methylation that is associated with autoimmune pathology. We investigated the association between MTHFR genetic polymorphisms at g.677C>T and g.1298A>C and their haplotypes, and the risk of thyroid dysfunction among Jordanian females. Subjects and methods A case-control study involving 98 hypothyroidism cases, 66 hyperthyroidism cases and 100 controls was conducted. Polymerase chain reaction/restriction fragment length polymorphism technique was performed to determine genotypes. Statistical analysis using SPSS software was performed. Results Genetic analysis showed a significant difference in genotype frequency of g.1298A>C between cases, and controls [hypothyroidism AA (45.9%), AC (37.8%), CC (16.3%); hyperthyroidism AA (9.1%), AC (69.7%), CC (21.2%); controls AA (37.8%), AC (29.6%), CC (32.7%); CChypo vs. AAhypo 2.55, 95% CI (1.18-5.52); OR at least on Chypo 1.79, 95% CI (1.07-2.99)]; CChyper vs. AAhyper 4.01, 95% CI (1.79-9.01); OR at least on Chyper 0.18, 95% CI (0.07-0.48)]. There was no significant difference in genotype frequency of g.677C>T between cases and controls [hypothyroidism CC (50.0%), CT (32.7%), TT (17.3%); hyperthyroidism CC (77.3%), CT (15.2%), TT (7.6%); controls CC (55.6%), CT (32.3%), TT (12.1%)]. There was a significant difference of MTHFR haplotypes among hypothyroidism cases and controls. TA and CC had a lower hypothyroidism risk whereas; TC showed a higher risk. Conclusions g.1298A>C genetic polymorphism of MTHFR may modulate the risk of thyroid disease. CC, TA, and TC haplotypes affect the risk of hypothyroidism. Larger samples should be included in the future to verify the role of MTHFR polymorphisms in thyroid diseases.
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Índice:
LILACS (Américas)
Asunto principal:
Polimorfismo de Longitud del Fragmento de Restricción
/
Polimorfismo de Nucleótido Simple
/
Metilenotetrahidrofolato Reductasa (NADPH2)
/
Hipertiroidismo
/
Hipotiroidismo
Tipo de estudio:
Estudio de etiología
/
Estudio observacional
/
Factores de riesgo
Límite:
Adulto
/
Femenino
/
Humanos
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Arch. endocrinol. metab. (Online)
Asunto de la revista:
Endocrinologia
/
Metabolismo
Año:
2019
Tipo del documento:
Artículo
País de afiliación:
Jordania
Institución/País de afiliación:
University of Jordan/JO
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