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Structural and functional neuroimaging studies in generalized anxiety disorder: a systematic review
Madonna, Domenico; Delvecchio, Giuseppe; Soares, Jair C; Brambilla, Paolo.
  • Madonna, Domenico; Universitá di Milano. Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti. IT
  • Delvecchio, Giuseppe; Universitá di Milano. Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti. IT
  • Soares, Jair C; University of Texas at Houston. Department of Psychiatry and Behavioral Neurosciences. TX. US
  • Brambilla, Paolo; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda Ospedale Maggiore Policlinico. Dipartimento di Neuroscienze e Salute Mentale. Milano. IT
Braz. J. Psychiatry (São Paulo, 1999, Impr.) ; 41(4): 336-362, July-Aug. 2019. tab, graf
Artículo en Inglés | LILACS | ID: biblio-1011505
ABSTRACT

Objectives:

Brain imaging studies carried out in patients suffering from generalized anxiety disorder (GAD) have contributed to better characterize the pathophysiological mechanisms underlying this disorder. The present study reviews the available functional and structural brain imaging evidence on GAD, and suggests further strategies for investigations in this field.

Methods:

A systematic literature review was performed in PubMed, PsycINFO, and Google Scholar, aiming to identify original research evaluating GAD patients with the use of structural and functional magnetic resonance imaging as well as diffusion tensor imaging.

Results:

The available studies have shown impairments in ventrolateral and dorsolateral prefrontal cortex, anterior cingulate, posterior parietal regions, and amygdala in both pediatric and adult GAD patients, mostly in the right hemisphere. However, the literature is often tentative, given that most studies have employed small samples and included patients with comorbidities or in current use of various medications. Finally, different methodological aspects, such as the type of imaging equipment used, also complicate the generalizability of the findings.

Conclusions:

Longitudinal neuroimaging studies with larger samples of both juvenile and adult GAD patients, as well as at risk individuals and unaffected relatives, should be carried out in order to shed light on the specific biological signature of GAD.
Asunto(s)


Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Trastornos de Ansiedad / Encéfalo / Imagen por Resonancia Magnética / Neuroimagen Funcional Tipo de estudio: Revisiones Sistemáticas Evaluadas Límite: Humanos Idioma: Inglés Revista: Braz. J. Psychiatry (São Paulo, 1999, Impr.) Asunto de la revista: Psiquiatria Año: 2019 Tipo del documento: Artículo País de afiliación: Italia / Estados Unidos Institución/País de afiliación: Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda Ospedale Maggiore Policlinico/IT / University of Texas at Houston/US / Universitá di Milano/IT

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Trastornos de Ansiedad / Encéfalo / Imagen por Resonancia Magnética / Neuroimagen Funcional Tipo de estudio: Revisiones Sistemáticas Evaluadas Límite: Humanos Idioma: Inglés Revista: Braz. J. Psychiatry (São Paulo, 1999, Impr.) Asunto de la revista: Psiquiatria Año: 2019 Tipo del documento: Artículo País de afiliación: Italia / Estados Unidos Institución/País de afiliación: Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda Ospedale Maggiore Policlinico/IT / University of Texas at Houston/US / Universitá di Milano/IT