Prediction of bone mass changes after successful parathyroidectomy using biochemical markers of bone metabolism in primary hyperparathyroidism: is it clinically useful?
Arch. endocrinol. metab. (Online)
;
63(4): 394-401, July-Aug. 2019. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-1019358
ABSTRACT
ABSTRACT Objective To measure type 1 serum amino-terminal propeptide procollagen (P1NP) and type 1 cross-linked C-terminal telopeptide collagen (CTX) before parathyroidectomy (PTX) in PHPT patients, correlating these measurements with bone mineral density (BMD) changes. Subjects and methods 31 primary hyperparathyroidism (HPTP) were followed from diagnosis up to 12-18 months after surgery. Serum levels of calcium, parathyroid hormone (PTH) vitamin D, CTX, P1NP, and BMD were measured before and 1 year after surgery. Results One year after PTX, the mean BMD increased by 8.6%, 5.5%, 5.5%, and 2.2% in the lumbar spine, femoral neck (FN), total hip (TH), and distal third of the nondominant radius (R33%), respectively. There was a significant correlation between BMD change 1 year after the PTX and CTX (L1-L4 r = 0.614, p < 0.0003; FN r = 0.497, p < 0.0051; TH r = 0.595, p < 0.0005; R33% r = 0.364, p < 0.043) and P1NP (L1-L4 r = 0,687, p < 0,0001; FN r = 0,533, p < 0,0024; TH r = 0,642, p < 0,0001; R33% r = 0,467, p < 0,0079) preoperative levels. The increase in 25(OH)D levels has no correlation with BMD increase (r = -0.135; p = 0.4816). On linear regression, a minimum preoperative CTX value of 0.331 ng/mL or P1NP of 37.9 ng/mL was associated with a minimum 4% increase in L1-L4 BMD. In TH, minimum preoperative values of 0.684 ng/mL for CTX and 76.0 ng/mL for P1NP were associated with a ≥ 4% increase in BMD. Conclusion PHPT patients presented a significant correlation between preoperative levels of turnover markers and BMD improvement 1 year after PTX.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Fragmentos de Péptidos
/
Péptidos
/
Densidad Ósea
/
Paratiroidectomía
/
Procolágeno
/
Colágeno Tipo I
/
Hiperparatiroidismo Primario
Tipo de estudio:
Estudio pronóstico
/
Factores de riesgo
Límite:
Anciano
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Arch. endocrinol. metab. (Online)
Asunto de la revista:
Endocrinologia
/
Metabolismo
Año:
2019
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Unifesp/BR
/
Universidade Federal de São Paulo/BR
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