Hepatitis C disease burden and strategies for elimination by 2030 in Brazil. A mathematical modeling approach
Braz. j. infect. dis
;
23(3): 182-190, May-June 2019. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-1019554
ABSTRACT
ABSTRACT Introduction and aim:
Hepatitis C is a key challenge to public health in Brazil. The objective of this paper was to describe the Brazilian strategy for hepatitis C to meet the 2030 elimination goal proposed by World Health Organization (WHO).Methods:
A mathematical modeling approach was used to estimate the current HCV-infected Brazilian population, and to evaluate the relative costs of two different scenarios to address HCV disease burden in Brazil (1) if no further changes are made to the HCV treatment program in Brazil; (2) where the WHO targets for 2030 elimination are met through diagnosis and treatment efforts peaking before 2024.Results:
An anti-HCV prevalence of 0.53% was calculated for the total population. It was estimated that the number of HCV-RNA+ individuals in Brazil in 2017 was 632,000 (0.31% of the population). Scale-up of treatment and diagnosis over time will be necessary in order to achieve WHO targets beginning in 2018. Direct costs (diagnostic, treatment and healthcare costs) are projected to increase significantly during the scale-up of treatment and diagnosis in the initial years of the intervention scenario, but then fall below the base case on an annual basis by 2025-2036, once HCV is eliminated, due to health sectors savings from the prevention of HCV liver-related morbidity and mortality.Conclusion:
Achieving the WHO targets is technically feasible in Brazil with a scale-up of treatment and diagnosis over time, beginning in 2018. However, elimination of hepatitis C requires policy changes to substantially scale-up prevention, screening and treatment of HCV, together with public health advocacy to raise awareness among affected populations and healthcare providers.
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Índice:
LILACS (Américas)
Asunto principal:
Hepatitis C
/
Hepacivirus
/
Erradicación de la Enfermedad
Tipo de estudio:
Estudio de incidencia
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Adolescente
/
Adulto
/
Anciano
/
Niño
/
Child, preschool
/
Humanos
/
Lactante
País/Región como asunto:
America del Sur
/
Brasil
Idioma:
Inglés
Revista:
Braz. j. infect. dis
Asunto de la revista:
Enfermedades Transmisibles
Año:
2019
Tipo del documento:
Artículo
País de afiliación:
Brasil
/
Estados Unidos
Institución/País de afiliación:
Center for Disease Analysis Foundation/US
/
Federal University of Mato Grosso/BR
/
Federal University of São Paulo/BR
/
AIDS and Viral Hepatitis+BR
/
Pan American Health Organization/US
/
University of São Paulo School of Medicine/BR
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