Tongue function, salivary flow rate and IgA, IgM and IgG total salivary levels in chronic chagasic patients
Rev. patol. trop
;
48(2): 109-120, 2019.
Artículo
en Inglés
| LILACS
| ID: biblio-1025836
ABSTRACT
Although microscopic alterations have been detected in tongues and salivary glands of chagasic patients and the identification of biomarkers in saliva has proved advantageous, there are no studies evaluating tongue function and total salivary IgA, IgG and IgM levels in chronic chagasic patients. The aim of this study was to evaluate tongue function, salivary flow rate, and total salivary IgA, IgG and IgM levels comparing chronic and non-infected individuals. 37 patients were selected chronic cardiac chagasic patients (n=6), chronic chagasic patients with the associated form of the disease (cardiopathy and megaesophagus) (n=11), and non-chagasic individuals (n=20). The tongue function underwent a phonoaudiological evaluation. The salivary flow rate was measured by sialometry. The total salivary IgA, IgG and IgM levels were evaluated by sandwich ELISA assay. Chagasic patients with the associated form of the disease presented higher salivary flow rate and lower salivary protein levels. No significant differences were noted in the lingual function or in the total salivary immunoglobulin levels among the groups. Although patients with chagasic megaesophagus presented higher levels of salivary flow and lower salivary protein, the fact that there were no significant differences in lingual function and total salivary immunoglobulin levels among the groups led to the conclusion that chronic chagas disease does not modify the lingual function or the total IgA, IgG and IgM salivary levels. The present study was the first to evaluate the function of the tongue and salivary total immunoglobulin levels in Chagas disease.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Enfermedades de las Glándulas Salivales
/
Glándulas Salivales
/
Inmunoglobulina A
/
Inmunoglobulina G
/
Inmunoglobulina M
/
Enfermedad de Chagas
Idioma:
Inglés
Revista:
Rev. patol. trop
Asunto de la revista:
Medicina Tropical
/
Patología
Año:
2019
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade de Uberaba/BR
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