Vitiligo patients show significant up-regulation of aryl hydrocarbon receptor transcription factor
An. bras. dermatol
;
93(2): 302-303, Mar.-Apr. 2018. graf
Artículo
en Inglés
| LILACS
| ID: biblio-1038265
ABSTRACT
Abstract IL-22 has been implicated in the pathogenesis of vitiligo. However, the role of aryl hydrocarbon receptor transcription factor that acts as a master regulator of IL-22-producing Th22 cells is not fully understood. The goal of this study was to investigate the expression pattern of aryl hydrocarbon receptor in peripheral blood mononuclear cells of patients with vitiligo and in normal controls. Transcript levels were determined by a reverse transcription quantitative real-time polymerase chain reaction. Aryl hydrocarbon receptor mRNA expression was drastically increased in patients with vitiligo compared to healthy controls (P = 0.000). Th22 cells may contribute to abnormal immune responses underlying vitiligo.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Vitíligo
/
Regulación hacia Arriba
/
Receptores de Hidrocarburo de Aril
/
Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico
Tipo de estudio:
Estudio observacional
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
An. bras. dermatol
Asunto de la revista:
Dermatologia
Año:
2018
Tipo del documento:
Artículo
País de afiliación:
Irán
Institución/País de afiliación:
National Institute of Genetic Engineering and Biotechnology Tehran/IR
/
Tehran University of Medical Sciences/IR
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