No detection of c-kit gene mutations in exons 9, 11, 13 and 17 and low CD117 expression in plaque-stage mycosis fungoides
An. bras. dermatol
;
93(6): 913-915, Nov.-Dec. 2018. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-1038285
ABSTRACT
Abstract The growth factor receptor c-kit (CD117) is expressed in immature T-cells and in some advanced forms of mycosis fungoides. c-kit gene mutation results in unrestricted neoplastic proliferation. We aimed to detect by PCR the most frequent exon mutations in seventeen plaque-stage MF patients, in their perilesional skin and in healthy skin donors. We secondarily evaluated CD117 expression by immunohistochemistry in plaque-stage and tumor-stage MF. We detected no mutation in c-kit gene and low CD117 expression was confirmed on atypical cells in one patient. Complete c-kit exon and intron sequences should be assessed and more sensitive sequencing method could be also applied.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Exones
/
Micosis Fungoide
/
Proteínas Proto-Oncogénicas c-kit
/
Mutación
Tipo de estudio:
Estudio diagnóstico
/
Estudio observacional
Límite:
Anciano
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
An. bras. dermatol
Asunto de la revista:
Dermatologia
Año:
2018
Tipo del documento:
Artículo
País de afiliación:
Argentina
Institución/País de afiliación:
Hospital Italiano de Buenos Aires/AR
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