Study of erythrocytes as a novel drug carrier for the delivery of artemether
Braz. J. Pharm. Sci. (Online)
;
55: e17680, 2019. graf
Artículo
en Inglés
| LILACS
| ID: biblio-1039046
ABSTRACT
Resealed erythrocytes have been explored in various dimensions of drug delivery, owing to their high biocompatibility and inability to initiate immune response. The present research was designed to evaluate the drug delivery potential of erythrocytes by loading a hydrophobic anti-malarial drug, Artemether. Three different loading techniques were applied to achieve maximum optimized drug loading. A HPLC method was validated for drug quantification in erythrocytes. The relatively high loading was achieved using hypotonic treatment was 31.39% as compared to other two methods. These, drug loaded erythrocytes were characterized for membrane integrity via ESR showing higher ESR values for drug loaded cells as compared to normal cells. Moreover, microscopic evaluation was done to observe morphological changes in erythrocytes after successful loading which showed swollen cells with slight rough surface as compared to smooth surface of normal cells. Drug release was studied for 8 h which showed more than 80% release within 3-7 h from erythrocytes treated with different hypotonic methods. Overall, the study revealed a potential application of erythrocytes in delivery of hydrophobic drugs using hypotonic treatment as compared to other methods.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Eritrocitos
/
Liberación de Fármacos
/
Arteméter
Idioma:
Inglés
Revista:
Braz. J. Pharm. Sci. (Online)
Asunto de la revista:
Farmacologia
/
Teraputica
/
Toxicologia
Año:
2019
Tipo del documento:
Artículo
País de afiliación:
Pakistán
Institución/País de afiliación:
Quaid-i-Azam University/PK
/
Riphah International University Lahore Campus/PK
/
University of Central Punjab/PK
/
University of Veterinary and Animal Sciences/PK
/
University of the Punjab/PK
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