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Study of erythrocytes as a novel drug carrier for the delivery of artemether
Riaz, Muhammad Ijaz; Sarwar, Hafiz Shoaib; Rehman, Mubashir; Gohar, Umar Farooq; Raza, Syed Atif; Siddique, Muhammad Irfan; Shahnaz, Gul; Sohail, Muhammad Farhan.
Afiliación
  • Riaz, Muhammad Ijaz; Riphah International University Lahore Campus. Riphah Institute of Pharmaceutical Sciences. Lahore. PK
  • Sarwar, Hafiz Shoaib; Riphah International University Lahore Campus. Riphah Institute of Pharmaceutical Sciences. Lahore. PK
  • Rehman, Mubashir; University of Central Punjab. Faculty of Pharmacy. Lahore. PK
  • Gohar, Umar Farooq; Riphah International University Lahore Campus. Riphah Institute of Pharmaceutical Sciences. Lahore. PK
  • Raza, Syed Atif; University of the Punjab. University College of Pharmacy. Allama Iqbal Campus. Lahore. PK
  • Siddique, Muhammad Irfan; University of Veterinary and Animal Sciences. Institute of Pharmaceutical Sciences. Lahore. PK
  • Shahnaz, Gul; Quaid-i-Azam University. Faculty of Biological Sciences. Department of Pharmacy. Islamabad. PK
  • Sohail, Muhammad Farhan; Riphah International University Lahore Campus. Riphah Institute of Pharmaceutical Sciences. Lahore. PK
Braz. J. Pharm. Sci. (Online) ; 55: e17680, 2019. graf
Article en En | LILACS | ID: biblio-1039046
Biblioteca responsable: BR40.1
Ubicación: BR40.1
ABSTRACT
Resealed erythrocytes have been explored in various dimensions of drug delivery, owing to their high biocompatibility and inability to initiate immune response. The present research was designed to evaluate the drug delivery potential of erythrocytes by loading a hydrophobic anti-malarial drug, Artemether. Three different loading techniques were applied to achieve maximum optimized drug loading. A HPLC method was validated for drug quantification in erythrocytes. The relatively high loading was achieved using hypotonic treatment was 31.39% as compared to other two methods. These, drug loaded erythrocytes were characterized for membrane integrity via ESR showing higher ESR values for drug loaded cells as compared to normal cells. Moreover, microscopic evaluation was done to observe morphological changes in erythrocytes after successful loading which showed swollen cells with slight rough surface as compared to smooth surface of normal cells. Drug release was studied for 8 h which showed more than 80% release within 3-7 h from erythrocytes treated with different hypotonic methods. Overall, the study revealed a potential application of erythrocytes in delivery of hydrophobic drugs using hypotonic treatment as compared to other methods.
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Texto completo: 1 Índice: LILACS Asunto principal: Eritrocitos / Liberación de Fármacos / Arteméter Idioma: En Revista: Braz. J. Pharm. Sci. (Online) Asunto de la revista: Farmacologia / Terapˆutica / Toxicologia Año: 2019 Tipo del documento: Article

Texto completo: 1 Índice: LILACS Asunto principal: Eritrocitos / Liberación de Fármacos / Arteméter Idioma: En Revista: Braz. J. Pharm. Sci. (Online) Asunto de la revista: Farmacologia / Terapˆutica / Toxicologia Año: 2019 Tipo del documento: Article