Reduction of venous pressure during the resection of liver metastases compromises enteric blood flow: IGFBP-1 as a novel biomarker of intestinal barrier injury
Clinics
;
72(10): 645-648, Oct. 2017. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-1039533
ABSTRACT
OBJECTIVES:
Disruption of the intestinal barrier and bacterial translocation commonly occur when intestinal blood flow is compromised. The aim of this study was to determine whether liver resection induces intestinal damage.METHODS:
We investigated intestinal fatty-acid binding protein and insulin-like growth factor binding protein levels in the plasma of patients who underwent liver resection.RESULTS:
We show that liver resection is associated with significant intestinal barrier injury, even if the Pringle maneuver is not performed.CONCLUSION:
We propose the use of insulin-like growth factor binding protein-1 as a novel biomarker of intestinal damage in such situations.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Presión Venosa
/
Proteína 1 de Unión a Factor de Crecimiento Similar a la Insulina
/
Hepatectomía
/
Mucosa Intestinal
/
Neoplasias Hepáticas
Límite:
Adulto
/
Anciano
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Clinics
Asunto de la revista:
Medicina
Año:
2017
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Hospital Sírio-Libanês/BR
/
Universidade de São Paulo/BR
Similares
MEDLINE
...
LILACS
LIS