Changes in the intestinal microbiota of superobese patients after bariatric surgery
Clinics
;
74: e1198, 2019. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-1039552
ABSTRACT
OBJECTIVES:
The gut microbiota is associated with obesity and weight loss after bariatric surgery and has been related to its changing pattern. Exactly how the bacterial population affects weight loss and the results of surgery remain controversial. This study aimed to evaluate the intestinal microbiota of superobese patients before and after gastric bypass surgery (RYGB).METHOD:
DNA fragments for the microbiota obtained from stool samples collected from nine superobese patients before and after bariatric surgery were sequenced using Ion Torrent.RESULTS:
We observed that with a mean follow-up of 15 months, patients achieved 55.9% excess weight loss (EWL). A significant population reduction in the Proteobacteria phylum (11 to 2%, p=0.0025) was observed after surgery, while no difference was seen in Firmicutes and Bacteroidetes. Further analyses performed with two specific individuals with divergent clinical outcomes showed a change in the pattern between them, with a significant increase in Firmicutes and a decrease in Bacteroidetes in the patient with less weight loss (%EWL 50.79 vs. 61.85).CONCLUSIONS:
RYGB affects the microbiota of superobese patients, with a significant reduction in Proteobacteria in patients with different weight loss, showing that different bacteria may contribute to the process.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Obesidad Mórbida
/
Pérdida de Peso
/
Cirugía Bariátrica
/
Microbioma Gastrointestinal
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Adolescente
/
Adulto
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Clinics
Asunto de la revista:
Medicina
Año:
2019
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo/BR
Similares
MEDLINE
...
LILACS
LIS