Association between calcitonin receptor gene polymorphisms and calcium stone urolithiasis: A meta-analysis
Int. braz. j. urol
;
45(5): 901-909, Sept.-Dec. 2019. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-1040082
ABSTRACT
ABSTRACT Purpose It has been reported that calcitonin receptor (CALCR) gene polymorphisms might be associated with calcium stone urolithiasis. Owing to mixed and inconclusive results, we conducted a meta-analysis to summarize and clarify this association. Materials and Methods A systematic search of studies on the association between CALCR gene polymorphisms and calcium stone urolithiasis susceptibility was conducted in databases. Results Odds ratios and 95% confidence intervals were used to pool the effect size. Five articles were included in our meta-analysis. Conclusions CALCR rs1801197 might be associated with increased risk of calcium stone urolithiasis. There is insufficient data to fully confirm the association between CALCR rs1042138 and calcium stone urolithiasis susceptibility. Well-designed studies with larger sample size and more subgroups are required to validate the risk identified in the current meta-analysis.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Receptores de Calcitonina
/
Polimorfismo de Nucleótido Simple
/
Urolitiasis
Tipo de estudio:
Estudio de etiología
/
Estudio pronóstico
/
Factores de riesgo
/
Revisiones Sistemáticas Evaluadas
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Int. braz. j. urol
Asunto de la revista:
Urología
Año:
2019
Tipo del documento:
Artículo
País de afiliación:
China
Institución/País de afiliación:
Fujian Medical University/CN
/
Xiamen University/CN
Similares
MEDLINE
...
LILACS
LIS