Evidence for regulated expression of Telomeric Repeat-containing RNAs (TERRA) in parasitic trypanosomatids
Mem. Inst. Oswaldo Cruz
;
112(8): 572-576, Aug. 2017. graf
Artículo
en Inglés
| LILACS
| ID: biblio-1040575
ABSTRACT
The Telomeric Repeat-containing RNAs (TERRA) participate in the homeostasis of telomeres in higher eukaryotes. Here, we investigated the expression of TERRA in Leishmania spp. and Trypanosoma brucei and found evidences for its expression as a specific RNA class. The trypanosomatid TERRA are heterogeneous in size and partially polyadenylated. The levels of TERRA transcripts appear to be modulated through the life cycle in both trypanosomatids investigated, suggesting that TERRA play a stage-specific role in the life cycle of these early-branching eukaryotes.
Texto completo:
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Índice:
LILACS (Américas)
Asunto principal:
Trypanosoma brucei brucei
/
ARN
/
Secuencias Repetitivas de Ácidos Nucleicos
/
Telomerasa
/
Leishmania
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
Medicina Tropical
/
Parasitología
Año:
2017
Tipo del documento:
Artículo
País de afiliación:
Brasil
/
Estados Unidos
Institución/País de afiliación:
Universidade de São Paulo/BR
/
Yale University/US
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