Novel variants of human herpesvirus 2 from Brazilian HIV-1 coinfected subjects
Mem. Inst. Oswaldo Cruz
;
113(12): e180328, 2018. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-1040588
ABSTRACT
BACKGROUND Human herpesvirus 2 (HHV-2) have DNA genome with a limited genetic variability and have been classified into two clades. OBJECTIVES To identify and characterise six HHV-2 isolates derived from Brazilian women. METHODS HHV-2 isolates were performed polymerase chain reaction (PCR) and sequencing of 2250 pb of the glycoprotein B (gB) coding regions. FINDINGS Four HHV-2 isolates were classified into clade B, while the remaining two, derived from HIV-1 co-infected women, showed a notable genetic divergence (> 1%). MAIN CONCLUSION The results reveal novel HHV-2 variants. The impact of these novel variants on HHV-2 pathogenesis and HIV/HHV-2 coinfection need to be investigated.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Herpes Genital
/
Infecciones por VIH
/
VIH-1
/
Herpesvirus Humano 2
/
Genes Virales
Tipo de estudio:
Estudio pronóstico
Límite:
Femenino
/
Humanos
País/Región como asunto:
America del Sur
/
Brasil
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
Medicina Tropical
/
Parasitología
Año:
2018
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Fundação Oswaldo Cruz-Fiocruz/BR
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