Potential application of rLc36 protein for diagnosis of canine visceral leishmaniasis
Mem. Inst. Oswaldo Cruz
;
113(3): 197-201, Mar. 2018. graf
Artículo
en Inglés
| LILACS
| ID: biblio-1040592
ABSTRACT
Visceral leishmaniasis (VL) is fatal if left untreated. Infected dogs are important reservoirs of the disease, and thus specific identification of infected animals is very important. Several diagnostic tests have been developed for canine VL (CVL); however, these tests show varied specificity and sensitivity. The present study describes the recombinant protein rLc36, expressed by Leishmania infantum, as potential antigen for more sensitive and specific diagnosis of CVL based on an immunoenzymatic assay. The concentration of 1.0 μg/mL of rLc36 enabled differentiation of positive and negative sera and showed a sensitivity of 85% and specificity of 71% (with 95% confidence), with an accuracy of 76%.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Proteínas Protozoarias
/
Leishmania infantum
/
Enfermedades de los Perros
/
Leishmaniasis Visceral
Tipo de estudio:
Estudio diagnóstico
/
Estudio pronóstico
Límite:
Animales
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
Medicina Tropical
/
Parasitología
Año:
2018
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade Estadual Paulista/BR
/
Universidade Federal de São Carlos/BR
/
Universidade de São Paulo/BR
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