Genomic analysis of bifunctional Class C-Class D ß-lactamases in environmental bacteria
Mem. Inst. Oswaldo Cruz
;
113(8): e180098, 2018. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-1040602
ABSTRACT
β-lactamases, which are found in several bacterial species and environments, are the main cause of resistance to β-lactams in Gram-negative bacteria. In 2009, a protein (LRA-13) with two β-lactamase domains (one class C domain and one class D domain) was experimentally characterised, and an extended action spectrum against β-lactams consistent with two functional domains was found. Here, we present the results of searches in the non-redundant NCBI protein database that revealed the existence of a group of homologous bifunctional β-lactamases in the genomes of environmental bacteria. These findings suggest that bifunctional β-lactamases are widespread in nature; these findings also raise concern that bifunctional β-lactamases may be transferred to bacteria of clinical importance through lateral gene transfer mechanisms.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Beta-Lactamasas
/
Dominio Catalítico
/
Genómica
/
Microbiología Ambiental
/
Bacterias Gramnegativas
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
Medicina Tropical
/
Parasitología
Año:
2018
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Fundação Oswaldo Cruz-Fiocruz/BR
Similares
MEDLINE
...
LILACS
LIS