Subversion of immunoproteasome subunit expression in dengue virus serotype 2-infected HepG2 cells
Rev. Soc. Bras. Med. Trop
;
50(1): 99-103, Jan.-Feb. 2017. graf
Artículo
en Inglés
| LILACS
| ID: biblio-1041391
ABSTRACT
Abstract INTRODUCTION:
Infection with all serotypes of dengue virus (DV) results in augmented antigen presentation by MHC class I molecules. However, the upregulation of immunoproteasome subunits only results from infection with two serotypes. This study aims to elucidate changes in the expression of immunoproteasome subunits resulting from infection with DV, particularly DV serotype 2 (DV2).METHODS:
HepG2 cells were grown in various culture milieu. Total cellular RNA and proteins were extracted and quantified.RESULTS:
Results demonstrated sequestration of immunoproteasome subunits LMP2 and LMP7 in DV2-infected cells.CONCLUSIONS:
This study provides insights into the mechanisms underlying immune evasion by DV.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Virus del Dengue
/
Complejo de la Endopetidasa Proteasomal
Límite:
Humanos
Idioma:
Inglés
Revista:
Rev. Soc. Bras. Med. Trop
Asunto de la revista:
Medicina Tropical
Año:
2017
Tipo del documento:
Artículo
País de afiliación:
Malasia
Institución/País de afiliación:
University of Malaya/MY
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