Impact of Bacille Calmette-Guérin revaccination on serum IgE levels in a randomized controlled trial
Rev. Soc. Bras. Med. Trop
;
51(1): 94-98, Jan.-Feb. 2018. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-1041447
ABSTRACT
Abstract INTRODUCTION:
Bacille Calmette-Guérin (BCG) downmodulates allergen-specific IgE levels and prevents other atopic responses in experimental models but fails to protect against respiratory allergies. Human responsiveness to BCG is variable and may interfere with protection.METHODS:
Multivariate models were evaluated to test the possible effect of responsiveness (assessed by IFN-γ production) to BCG revaccination on the modulation of total and allergen-specific serum IgE levels in healthy volunteers participating in a randomized controlled trial.RESULTS:
Serum total or Derp-specific IgE levels did not change regardless of the increase in IFN-γ levels.CONCLUSIONS:
BCG responsiveness does not affect protection against atopy.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Inmunoglobulina E
/
Vacuna BCG
/
Inmunización Secundaria
/
Interferón gamma
Tipo de estudio:
Ensayo Clínico Controlado
/
Estudio pronóstico
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Rev. Soc. Bras. Med. Trop
Asunto de la revista:
Medicina Tropical
Año:
2018
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Fundação Oswaldo Cruz/BR
/
Universidade Federal da Bahia/BR
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