Maternal schistosomiasis: IL-2, IL-10 and regulatory T lymphocytes to unrelated antigen in adult offspring mice
Rev. Soc. Bras. Med. Trop
;
51(4): 546-549, July-Aug. 2018. graf
Artículo
en Inglés
| LILACS
| ID: biblio-1041472
ABSTRACT
Abstract INTRODUCTION:
We evaluated IL-10, IL-2 and regulatory T cells (Treg), in response to ovalbumin (OA), in offspring from schistosomotic mouse mothers.METHODS:
We used animals born (BIM) or suckled (SIM) from infected mothers; and mice born/suckled from infected (BSIM) or non-infected mothers (CONTROL). After OA+adjuvant immunization, spleen cells were cultured, with or without OA, and doubly marked for cytometry.RESULTS:
BIM showed fewer CD4+/IL-2+ and more B220+/IL-10+ cells, whereas the SIM group showed increased Treg frequency. BSIM had fewer B220+/IL-10+ and Treg cells.CONCLUSIONS:
Separately, gestation or nursing induced immunosuppressive cells in infected mothers, but improved anti-OA immunity when combined.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Esquistosomiasis mansoni
/
Anticuerpos Antihelmínticos
/
Interleucina-2
/
Interleucina-10
/
Linfocitos T Reguladores
/
Animales Lactantes
Límite:
Animales
Idioma:
Inglés
Revista:
Rev. Soc. Bras. Med. Trop
Asunto de la revista:
Medicina Tropical
Año:
2018
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Fundação Oswaldo Cruz/BR
/
Universidade Federal de Pernambuco/BR
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