TGF-ß1 polymorphism in American tegumentary leishmaniasis in a Southern Brazilian population
Rev. Soc. Bras. Med. Trop
; 52: e20170415, 2019. tab
Article
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| ID: biblio-1041504
Biblioteca responsable:
BR1.1
ABSTRACT
Abstract INTRODUCTION:
Genetic polymorphisms define the cytokine production leading to susceptibility or resistance to diseases. We studied the cytokine polymorphism in the development of tegumentary leishmaniasis (TL).METHODS:
Genotyping of TNF-α, TGF-β1, IFN-γ, IL-6, and IL-10 were performed by polymerase chain reaction assay.RESULTS:
G and C alleles of TGF- β1 (codon 25) were the most common in controls and patients, respectively. G/G was the most frequent genotype in controls, and G/C and C/C in patients.CONCLUSIONS:
G/G genotype of codon 25 in TGF-β1 appeared to confer resistance, and G/C and C/C genotypes, susceptibility to TL in this population.Palabras clave
Texto completo:
1
Índice:
LILACS
Asunto principal:
Mordeduras de Serpientes
/
Serpientes
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
/
Female
/
Humans
/
Male
País/Región como asunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Rev. Soc. Bras. Med. Trop
Asunto de la revista:
MEDICINA TROPICAL
Año:
2019
Tipo del documento:
Article