Relationships between phagocytosis, mucoid phenotype, and genetic characteristics of Klebsiella pneumoniae clinical isolates
Rev. Soc. Bras. Med. Trop
;
52: e20190089B, 2019. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-1041519
ABSTRACT
Abstract INTRODUCTION The relationships between phagocytosis, and mucoid phenotype, plasmid profile and virulence, and resistance genetic characteristics of Klebsiella pneumoniae clinical isolates were evaluated. METHODS Thirty isolates were used to determine the mucoid aspect. Four were selected for analysis of phagocytosis by alveolar macrophages. RESULTS Thirty percent of the samples presented the mucoid phenotype. The phagocytosis rate ranged from 21.5% to 43.43%. Phagocytosis was not correlated with the plasmid profile, but was apparently correlated with mucoid phenotype and antibiotic susceptibility. CONCLUSIONS: Several virulence factors act in parallel in K. pneumoniae to impair host defense.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Fagocitosis
/
Virulencia
/
Farmacorresistencia Microbiana
/
Factores de Virulencia
/
Klebsiella pneumoniae
/
Antibacterianos
Límite:
Humanos
Idioma:
Inglés
Revista:
Rev. Soc. Bras. Med. Trop
Asunto de la revista:
Medicina Tropical
Año:
2019
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade Estadual de Ciências da Saúde de Alagoas/BR
/
Universidade Federal de Pernambuco/BR
/
Universidade de São Paulo/BR
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