Effect of artemisinin-piperaquine treatment on the electrocardiogram of malaria patients
Rev. Soc. Bras. Med. Trop
;
52: e20180453, 2019. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-1041531
ABSTRACT
Abstract INTRODUCTION:
Concern regarding the cardiotoxicity of antimalarials has been renewed because of their potential to cause QT/QTc interval prolongation related to torsade de pointes (TdP). Artemisinin-piperaquine (AP) is considered an effective artemisinin-based combination therapy (ACT) for malaria.METHODS:
This study involved a retrospective analysis of clinical data of 93 hospitalized malaria patients who had received AP orally. Electrocardiograms (ECGs) were obtained at specific time points in the original study.RESULTS:
Some cases of QT prolongation were observed. However, no TdP was found.CONCLUSIONS:
AP may cause QT interval prolongation in some malaria patients but may not lead to TdP.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Quinolinas
/
Síndrome de QT Prolongado
/
Malaria Falciparum
/
Artemisininas
/
Antimaláricos
Tipo de estudio:
Estudio diagnóstico
/
Estudio observacional
/
Factores de riesgo
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Rev. Soc. Bras. Med. Trop
Asunto de la revista:
Medicina Tropical
Año:
2019
Tipo del documento:
Artículo
País de afiliación:
China
Institución/País de afiliación:
Guangzhou University of Chinese Medicine/CN
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