Plasmodium falciparum malarial parasites from Brazil lack artemisinin resistance-associated mutations in the kelch13 gene
Rev. Soc. Bras. Med. Trop
;
52: e20180225, 2019. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-1041579
ABSTRACT
Abstract INTRODUCTION Mutations in the propeller domain of the Plasmodium falciparum kelch13 (k13) gene are associated with artemisinin resistance. METHODS: We developed a PCR protocol to sequence the pfk13 gene and determined its sequence in a batch of 50 samples collected from 2003 to 2016 in Brazil. RESULTS: We identified 1 K189T substitution located outside the propeller domain of the PfK13 protein in 36% of samples. CONCLUSIONS: Although the sample size is relatively small, these results suggest that P. falciparum artemisinin-resistant mutants do not exist in Brazil, thereby supporting the continuation of current treatment programs based on artemisinin-based combination therapy.
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Asunto principal:
Plasmodium falciparum
/
Resistencia a Medicamentos
/
Proteínas Protozoarias
/
Malaria Falciparum
/
Artemisininas
/
Mutación
Tipo de estudio:
Guía de Práctica Clínica
/
Factores de riesgo
Límite:
Humanos
País/Región como asunto:
America del Sur
/
Brasil
Idioma:
Inglés
Revista:
Rev. Soc. Bras. Med. Trop
Asunto de la revista:
Medicina Tropical
Año:
2019
Tipo del documento:
Artículo
País de afiliación:
Brasil
/
Portugal
Institución/País de afiliación:
Ministério da Saúde/BR
/
Universidade Federal de Fluminense/BR
/
Universidade Federal de Goiás/BR
/
Universidade Federal do Rio de Janeiro/BR
/
Universidade Nova de Lisboa/PT
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