HPA-1a/1b could be considered a molecular predictor of poor prognosis in chronic hepatitis C
Rev. Soc. Bras. Med. Trop
;
52: e20170427, 2019. tab
Artículo
en Inglés
| LILACS
| ID: biblio-1041583
ABSTRACT
Abstract INTRODUCTION:
HPA polymorphism has been associated with HCV presence and fibrosis progression in chronic hepatitis C. However, it is unknown if there is an association between HPA-1 polymorphism and hepatocellular carcinoma (HCC). Therefore, this study aimed to evaluate HPA-1 polymorphism in the presence of HCC.METHODS:
PCR-SSP was used to perform HPA genotyping on 76 HCV-infected patients.RESULTS:
There was no association between patients with and without HCC. There was significant difference in HPA-1 genotypic frequency distribution between HCC and F1/F2 fibrosis degree.CONCLUSIONS:
The HPA-1a/1b polymorphism appears to be more associated with liver damage progression than with HCC presence.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Antígenos de Plaqueta Humana
/
Carcinoma Hepatocelular
/
Hepatitis C Crónica
/
Neoplasias Hepáticas
Tipo de estudio:
Estudio de etiología
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Rev. Soc. Bras. Med. Trop
Asunto de la revista:
Medicina Tropical
Año:
2019
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade Estadual Paulista/BR
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