Cytotoxicity, antioxidant and antibacterial activity of four compounds produced by an endophytic fungus Epicoccum nigrum associated with Entada abyssinica
Rev. bras. farmacogn
;
27(2): 251-253, Mar.-Apr. 2017. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-1042249
ABSTRACT
ABSTRACT Four compounds including beauvericin, parahydroxybenzaldehyde, indole-3-carboxylic acid and quinizarin were isolated from endophytic fungus Epicoccum nigrum and their cytotoxicity, antibacterial and antioxidant activity were evaluated. Beauvericin had remarkable activity against two Gram-negative strains (Bacillus cereus and Salmonella typhimurium) with respective MIC values of 3.12 and 6.25 µg/ml. All the compounds had weak cytotoxic effect on both normal and tumor cells. LC50 values ranged from 40.42 to 86.56 µg/ml, 31.87 to 86.57 µg/ml and 21.59 to 67.27 µg/ml on Vero cells, THP-1 and RAW 264.7 respectively. The present study showed that these compounds could be developed for the formulation of antioxidant-rich therapeutic diets and as a therapeutic agent against bacterial infections.
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Índice:
LILACS (Américas)
Tipo de estudio:
Factores de riesgo
Idioma:
Inglés
Revista:
Rev. bras. farmacogn
Asunto de la revista:
Farmacia
Año:
2017
Tipo del documento:
Artículo
País de afiliación:
Camerún
/
Sudáfrica
Institución/País de afiliación:
University of Pretoria/ZA
/
University of Yaoundé I/CM
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