Sensibilidad diagnóstica de electroforesis de proteínas y cadenas livianas libres séricas en gammapatías monoclonales / Diagnostic accuracy of serum protein electrophoresis and free light chain measurements for monoclonal gammopathies
Rev. méd. Chile
;
146(1): 64-67, ene. 2018. tab
Artículo
en Español
| LILACS
| ID: biblio-1043145
ABSTRACT
Background:
International guidelines suggest a screening panel for monoclonal gammopathies that contains serum protein electrophoresis (SPE), free light chain (FLC) measurements and immunofixation. This combination provides the possibility of a timely accurate diagnosis.Aim:
To evaluate the sensibility of a simple screening panel (SPE + FLC). Material andMethods:
We analyzed 191 consecutive serum samples of patients with a suspected monoclonal gammopathy (MG).Results:
Seventy five patients were diagnosed with MG. The sensitivity and specificity of the combination of SPE + FLC for the diagnosis of monoclonal gammopathy were 95% (95% confidence intervals 89-99) and 99% (95% confidence intervals 96-100), respectively.Conclusions:
We were able to validate the international recommendations on the diagnostic accuracy of this simple combination of two tests in serum for monoclonal gammopathy.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Paraproteinemias
/
Electroforesis de las Proteínas Sanguíneas
/
Cadenas Ligeras de Inmunoglobulina
Tipo de estudio:
Estudio diagnóstico
/
Guía de Práctica Clínica
/
Estudio observacional
Límite:
Humanos
Idioma:
Español
Revista:
Rev. méd. Chile
Asunto de la revista:
Medicina
Año:
2018
Tipo del documento:
Artículo
País de afiliación:
Argentina
/
Chile
Institución/País de afiliación:
Hospital del Salvador/CL
/
The Binding Site/AR
Similares
MEDLINE
...
LILACS
LIS