Molecular Epidemiology of Neisseria meningitidis Serogroup B in Brazil
Plos one
;
7(3): e33016, 2012. graf
Artículo
en Inglés
| SES-SP, LILACS, SESSP-CTDPROD, SES-SP
| ID: biblio-1052243
ABSTRACT
Background:
Neisseria meningitidis serogroup B has been predominant in Brazil, but no broadly effective vaccine is available to prevent endemic meningococcal disease. To understand genetic diversity among serogroup B strains in Brazil, we selected a nationally representative sample of clinical disease isolates from 2004, and a temporally representative sample for the state of SaËo Paulo (19882006) for study (n = 372).Methods:
We performed multi-locus sequence typing (MLST) and sequence analysis of five outer membrane protein (OMP) genes, including novel vaccine targets fHbp and nadA.Results:
In 2004, strain B4P1.15,19 clonal complex ST-32/ET-5 (cc32) predominated throughout Brazil; regional variation in MLST sequence type (ST), fetA, and porB was significant but diversity was limited for nadA and fHbp. Between 1988 and 1996, the SaËo Paulo isolates shifted from clonal complex ST-41/44/Lineage 3 (cc41/44) to cc32. OMP variation was associated with but not predicted by cc or ST. Overall, fHbp variant 1/subfamily B was present in 80% of isolates and showed little diversity. The majority of nadA were similar to reference allele 1.Conclusions:
A predominant serogroup B lineage has circulated in Brazil for over a decade with significant regional and temporal diversity in ST, fetA, and porB, but not in nadA and fHbp.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Epidemiología
/
Epidemiología Molecular
/
Meningitis
Tipo de estudio:
Estudio de tamizaje
País/Región como asunto:
America del Sur
/
Brasil
Idioma:
Inglés
Revista:
Plos one
Año:
2012
Tipo del documento:
Artículo
Institución/País de afiliación:
Center for Biologics Evaluation and Research/US
/
Institute of Allegry and Infectious Diseases/GB
/
Institute of Allegy and infectious/GB
/
Instituto Oswaldo Cruz/BR
/
J. Craig Institute (JCVI)/GB
/
Secretaria da Saúde do Estado de São Paulo/BR
/
University of Pittsburgh/US
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