Characterization of the intestinal graft in a swine hypotensive after brain death model
Acta cir. bras
;
34(11): e201901107, Nov. 2019. graf
Artículo
en Inglés
| LILACS
| ID: biblio-1054678
ABSTRACT
Abstract Purpose:
To establish a hypotensive brain death pig model and observe the effects of hypotension on small bowel donors.Methods:
The hypotensive brain death model was produced using the modified intracranial water sac inflation method in ten domestic crossbred pigs. Effects of hypotensive brain death on small bowel tissue morphology were evaluated through changes in intestinal tissue pathology, tight junction protein of the intestinal mucosa and plasma intestinal fatty acid-binding protein (i-FABP) levels. The pathophysiological mechanism was examined based on changes in superior mesenteric artery (SMA) blood flow and systemic hemodynamics.Results:
After model establishment, SMA blood flow, and the mean arterial pressure (MAP) significantly decreased, while heart rate increased rapidly and fluctuated significantly. Small bowel tissue morphology and levels of tight junction protein of the intestinal mucosa showed that after model establishment, small bowel tissue injury was gradually aggravated over time (P<0.05). Plasma i-FABP levels significantly increased after brain death (P<0.05).Conclusions:
A hypotensive brain death pig model was successfully established using an improved intracranial water sac inflation method. This method offers a possibility of describing the injury mechanisms more clearly during and after brain death.
Texto completo:
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Índice:
LILACS (Américas)
Asunto principal:
Muerte Encefálica
/
Modelos Animales de Enfermedad
/
Hipotensión
/
Intestino Delgado
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Inglés
Revista:
Acta cir. bras
Asunto de la revista:
Cirugía General
/
Procedimentos Cir£rgicos Operat¢rios
Año:
2019
Tipo del documento:
Artículo
País de afiliación:
China
Institución/País de afiliación:
Linyi Municipal Mental Health Center/CN
/
Xuzhou Medical University/CN
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