Effect of norbixin-based poly(hydroxybutyrate) membranes on the tendon repair process after tenotomy in rats
Acta cir. bras
;
34(11): e201901101, Nov. 2019. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-1054681
ABSTRACT
Abstract Purpose: To determine the efficacy of norbixin-based poly(hydroxybutyrate) (PHB) membranes for Achilles tendon repair. Methods: Thirty rats were submitted to total tenotomy surgery of the right Achilles tendon and divided into two groups (control and membrane; n = 15 each), which were further subdivided into three subgroups (days 7, 14, and 21; n = 5 each). Samples were analyzed histologically. Results: Histological analysis showed a significant reduction in inflammatory infiltrates on days 7, 14 (p < 0.0001 for both), and 21 (p = 0.0004) in the membrane group compared to that in the control group. There was also a significant decrease in the number of fibroblasts in the control group on days 7, 14 (p < 0.0001), and 21 (p = 0.0032). Further, an increase in type I collagen deposition was observed in the membrane group compared to that in the control group on days 7 (p = 0.0133) and 14 (p = 0.0107). Conclusion: Treatment with norbixin-based PHB membranes reduces the inflammatory response, increases fibroblast proliferation, and improves collagen production in the tendon repair region, especially between days 7 and 14.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Poliésteres
/
Tendón Calcáneo
/
Carotenoides
/
Tenotomía
/
Hidroxibutiratos
Tipo de estudio:
Estudios de evaluación
Límite:
Animales
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Acta cir. bras
Asunto de la revista:
Cirugía General
/
Procedimentos Cir£rgicos Operat¢rios
Año:
2019
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
IFPI/BR
/
UESPI/BR
/
UNIVAP/BR
/
Universidade Federal do Ceará/BR
/
Universidade Federal do Piauí/BR
/
Universidade do Vale do Paraíba/BR
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