Effects of huperzine A on hippocampal inflammatory response and neurotrophic factors in aged rats after anesthesia
Acta cir. bras
;
34(12): e201901205, 2019. graf
Artículo
en Inglés
| LILACS
| ID: biblio-1054687
ABSTRACT
Abstract Purpose To investigate the effects of huperzine A (HupA) on hippocampal inflammatory response and neurotrophic factors in aged rats after anesthesia. Methods Thirty-six Sprague Dawley rats (20-22 months old) were randomly divided into control, isofluran, and isoflurane+HupA groups; 12 rats in each group. The isoflurane+HupA group was intraperitoneally injected with 0.2 mg/kg of HupA. After 30 min, isoflurane inhalation anesthesia was performed in the isoflurane and isoflurane+HupA groups. After 24 h from anesthesia, Morris water maze experiment and open-field test were performed. Hippocampal inflammatory and neurotrophic factors were determined. Results Compared with isoflurane group, in isofluran+HupA group the escape latency of rats was significantly decreased (P < 0.05), the original platform quadrant residence time and traversing times were significantly increased (P < 0.05), the central area residence time was significantly increased (P < 0.05), the hippocampal tumor necrosis factor α, interleukin 6 and interleukin 1β levels were significantly decreased (P < 0.05), and the hippocampal nerve growth factor, brain derived neurotrophic factor and neurotrophin-3 levels were significantly increased (P < 0.05). Conclusion HupA may alleviate the cognitive impairment in rats after isoflurane anesthesia by decreasing inflammatory factors and increasing hippocampal neurotrophic factors in hippocampus tissue.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Sesquiterpenos
/
Fármacos Neuroprotectores
/
Anestésicos por Inhalación
/
Alcaloides
/
Hipocampo
/
Factores de Crecimiento Nervioso
Tipo de estudio:
Ensayo Clínico Controlado
/
Estudios de evaluación
Límite:
Animales
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Acta cir. bras
Asunto de la revista:
Cirugía General
/
Procedimentos Cir£rgicos Operat¢rios
Año:
2019
Tipo del documento:
Artículo
País de afiliación:
China
Institución/País de afiliación:
Chongqing Medical University/CN
/
People's Hospital of Bishan District/CN
Similares
MEDLINE
...
LILACS
LIS