Mesenchymal Stromal Cells Modulate PAF-stimulated Equine Alveolar Macrophages

Department of Animal ScienceMichelotto, Pedro Vicente; Department of Animal ScienceBastos, Fernanda Zettel; Department of Animal ScienceBarussi, Fernanda Cristina Mendes; Laboratory for Experimental Cell CultureSenegaglia, Alexandra Cristina; Nishiyama, Anita

Department of Animal ScienceMichelotto, Pedro Vicente; Department of Animal ScienceBastos, Fernanda Zettel; Department of Animal ScienceBarussi, Fernanda Cristina Mendes; Laboratory for Experimental Cell CultureSenegaglia, Alexandra Cristina; Nishiyama, Anita.

Department of Animal ScienceMichelotto, Pedro Vicente; Pontifical Catholic University. School of Life Sciences. Department of Animal ScienceMichelotto, Pedro Vicente. Curitiba. BR
Department of Animal ScienceBastos, Fernanda Zettel; Pontifical Catholic University. School of Life Sciences. Department of Animal ScienceBastos, Fernanda Zettel. Curitiba. BR
Department of Animal ScienceBarussi, Fernanda Cristina Mendes; Pontifical Catholic University. School of Life Sciences. Department of Animal ScienceBarussi, Fernanda Cristina Mendes. Curitiba. BR
Laboratory for Experimental Cell CultureSenegaglia, Alexandra Cristina; Pontifical Catholic University. School of Medicine. Laboratory for Experimental Cell CultureSenegaglia, Alexandra Cristina. Curitiba. BR
Nishiyama, Anita; Federal University of Paraná. Department of Physiology. Curitiba. BR

Braz. arch. biol. technol ; 62: e19180362, 2019. graf

Artículo en Inglés | LILACS | ID: biblio-1055420

ABSTRACT

ABSTRACT

Abstract Platelet-activating factor (PAF) is a potent proinflammatory mediator that is produced in increased amounts in the lungs of asthmatic humans and horses. The present pilot study, shows that mesenchymal stromal cells can modulate alveolar macrophage function in asthma, interfering in the activity of PAF, being another potential pathway for mesenchymal stromal cells benefits in asthma.

Asunto(s)

Animales; Asma/terapia; Factor de Activación Plaquetaria/uso terapéutico; Tratamiento Basado en Trasplante de Células y Tejidos/métodos; Caballos

Asthma; Horses; Lung; Platelet-activating factor; Pulmonary inflammation

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Asma / Factor de Activación Plaquetaria / Tratamiento Basado en Trasplante de Células y Tejidos / Caballos Límite: Animales Idioma: Inglés Revista: Braz. arch. biol. technol Asunto de la revista: Biologia Año: 2019 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Federal University of Paraná/BR / Pontifical Catholic University/BR

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